99%+ Purity Pregnenolone Pure Powder

Product Details:

 

Pregnenolone Powder Information
Pregnenolone Price100gAccording to your needs
500gAccording to your needs
1000gAccording to your needs
Steroid packagingSpecial stealth packaging through Customs
Delivery timeAbout 7 days
ShippingEMS, Hongkong Post, DHL, TNT, Fedex
Payment termsWU, MG, Bitcoin, T/T
Minimum order

10g powder

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99%+ Purity Pregnenolone Pure Powder

 

Pregnenolone Details:

Product Name: Pregnenolone
Synonyms: DELTA5-PREGNEN-3BETA-OL-20-ONE;DELTA5-PREGNEN-3B-OL-20-ONE;DELTA-5-PREGNENE-3B-OL-20-ONE;DELTA5-PREGNENOLONE;1-((3S,8S,9S,10R,13S,14S,17S)-3-HYDROXY-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-ETHANONE;3BETA-HYDROXY-5-PREGNEN-20-ONE;3BETA-HYDROXYPREGN-5-EN-20-ONE;3b-hydroxy-5-pregnen-20-one
CAS: 145-13-1
MF: C21H32O2
MW: 316.48
EINECS: 205-647-4
Chemical Properties white to off-white powder
Usage glucocortcoid, antiinflammatory
Usage Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A

 

Pregnenolone Specifications:

COA

Test

Result

Specification

Appearance

Qualified

White crystalline powder

Melting point

182~190.5℃

180~193℃

Loss on drying

0.22%

0.50%max

Specific rotation

+28°

+27°~+30°

Identification(TLC)

Conform to standard

Identical with and at least nearly equivalent to the pregnenolone

reference standard with reference to integrity, intensity, spot color

and RF value, compared to sample FR0025

Related substances (HPLC)

Any single
impurities: 0.30a/a%

Δ14-pregnenolone: ≤0.3a/a%

17-Alpha: ≤0.3a/a%

5α/β-pregnenolone≤0.4 a/a%

Any single impurity: ≤0.4 a/a%

0.64%

Total impurities: ≤1.0 a/a%

Assay (dried basis)

99.36%

99.36%

 

Pregnenolone Descriptions:

Pregnenolone (3β-hydroxypregn-5-en-20-one), also known as P5, is an endogenous steroid hormone. It is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. In addition, pregnenolone is biologically active in its own right, acting as a neurosteroid.

Like other steroids, pregnenolone consists of four interconnected cyclic hydrocarbons. It contains ketone and hydroxyl functional groups, two methyl branches, and a double bond at C5, in the B cyclic hydrocarbon ring. Like many steroid hormones, it is hydrophobic. Its esterified version, pregnenolone sulfate, is water-soluble.

Pregnenolone undergoes further steroid metabolism in one of three ways.
Pregnenolone can be converted to progesterone. The critical enzyme step is two-fold using a 3-beta-hydroxysteroid dehydrogenase and a delta 4-5 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the delta-4-pathway, resulting in production of 17-hydroxy progesterone and androstenedione, precursor to testosterone and estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.
Pregnenolone can be converted to 17-hydroxy-pregnenolone by the enzyme 17α-hydroxylase (CYP17A1). Using this pathway, termed delta-5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) using a desmolase. DHEA is the precursor of androstenedione.
Pregnenolone can be converted to androsta-5,16-dien-3 beta-ol by 16-ene synthetase.

 

Pregnenolone Usage:

Pregnenolone is used for fatigue and increasing energy; Alzheimer's disease and enhancing memory; trauma and injuries; as well as stress and improving immunity.
It is also is used for skin disorders including psoriasis and scleroderma.
Women use pregnenolone for lumpy breasts (fibrocystic breast disease), a disorder of the lining of the uterus (endometriosis), symptoms of menopause, andpremenstrual syndrome (PMS).
Some people use pregnenolone for slowing or reversing aging, arthritis, anddepression. It is also used for strengthening the heart, allergic reactions, "detoxification," lupus, multiple sclerosis (MS), prostate problems, and seizures.

 

Pregnenolone Dosage:

The appropriate dose of pregnenolone depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for pregnenolone. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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