Product Name :GDF-8
Place of Origin:China
Minimum Order Quantity:10 vials
Payment Terms:Western Union,Money Gram ,Bitcoin or T/T
Supply Ability:5000 Vial per month
Delivery Time:After receipt of your payment
Packaging Details:Original Kits or as requirements
Product Name:GDF-8,Peptide Hormones,Bodybuilding Supplements
Unit Size :1 mg/vial
Unit Quantity :1 Vial
Appearance :White Powder
Source :Chemical Synthesis
Storage :Lyophilized GDF-8 is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting MGF should be refrigerated at temperatures not to exceed 36 F.
Amino Acid Sequence
Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Asp-Phe-Gly-Leu-Asp.
Additional sequence information:The sequence of the first five N-terminal amino acids was determined and was found to be Asp-Phe-Gly-Leu-Asp so starting at aa 267.
Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
Biological activity:The ED50 as determined by the inhibition of the proliferation of MPC-11 cells is < 20ng/ml, corresponding to a Specific Activity of 50,000units/mg.
Purity:> 95 % SDS-PAGE.
This product is purified by proprietary chromatographic techniques. Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Additional notes:For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Preparation and Storage:
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute in sterile 20mM HCl at 0.1 mg/ml, which can then be further diluted to other aqueous solutions.
Growth differentiation factor 8
Growth/differentiation factor 8
Acts specifically as a negative regulator of skeletal muscle growth.
Belongs to the TGF-beta family.