99%+ Purity Chlormadinone Acetate (CMA) Pure Powder

Product Details:

99%+ Purity Chlormadinone Acetate (CMA) Pure Powder

Chlormadinone Acetate (CMA) Details:

Product Name:Chlormadinone Acetate
Alias:17-Acetoxy-6-Chloro-6-Dehydroprogesterone; 6-Chloro-3,20-Dioxopregna-4,6-Dien-17-Yl Acetate; (8Xi,9Xi,14Xi)-6-Chloro-3,20-Dioxopregna-4,6-Dien-17-Yl Acetate; CMA; Clordion, Gestafortin, Lormin, Non-Ovlon, Normenon, Verton
MF:C23H29ClO4
MW:404.927
CAS:302-22-7
EINECS:206-118-0
Appearance:White crystalline powder

Chlormadinone Acetate (CMA) Specifications:

COA

Chlormadinone Acetate (CMA) Descriptions:

(1) Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999.

(2) Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT).

(3) In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.

(4) The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.

(5) Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.

(6) The more recent application of CMA as an oral contraceptive in combination with EE (Neo Eunomin, Belara) has proven highly successful, with studies reporting excellent contraceptive efficacy, high tolerability and adherence due to a good side effect profile and positive effects on preexisting dysmenorrhea, skin and hair conditions.

Chlormadinone Acetate (CMA) Effects:

Progestogen

CMA acts predominantly as a potent progestogen, but also as an antiandrogen. Due to its potent actions as a progestogen, CMA also has strong antigonadotropic properties, and thus additional antiandrogen as well as antiestrogen properties.

Antiandrogen

Like other steroidal progestins with antiandrogen properties such as cyproterone acetate, medroxyprogesterone acetate, and megestrol acetate, as well as spironolactone (a steroidal antimineralocorticoid with antiandrogen and progestogen properties), but unlike non-steroidal antiandrogens such as flutamide and bicalutamide, CMA is not a silent antagonist of the androgen receptor (AR) but rather a weak partial agonist of the AR with the capacity to activate the receptor in the absence of more efficacious agonists such as testosterone.

Glucocorticoid

Similarly to other 17α-hydroxyprogesterone derivatives such as cyproterone acetate, medroxyprogesterone acetate, and megestrol acetate, CMA is a weak glucocorticoid, and has the potential to cause adrenal insufficiency upon abrupt discontinuation of the drug at sufficient dosages.

5α-Reductase

Chlormadinone acetate is a competitive inhibitor of 5α-reductase.

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