99%+ Purity Dapoxetine (S-Dapoxetine /DL-Dapoxetine) CAS No.:119356-77-3
Product Details:
| Dapoxetine Powder Information | ||
| Dapoxetine Price | 100g | According to your needs |
| 500g | According to your needs | |
| 1000g | According to your needs | |
| Packaging | discreet packages | |
| Delivery time | About 7 days | |
| Shipping | EMS, Hongkong Post, DHL, TNT, Fedex and so on. | |
| Payment terms | WU, MG, Bitcoin, T/T | |
| Minimum order | 10g powder | |
99%+ Purity Dapoxetine (S-Dapoxetine /DL-Dapoxetine) CAS No.:119356-77-3
Dapoxetine
Alias: Dapoxetine,d-Dapoxetine; DL-Dapoxetine
CAS Registry Number:119356-77-3
Assay: 99% min.
MF: C21H23NO.ClH
MW: 341.88
Related Substances: Pharmaceutical Grade
Storage: Shading, confined preservation
Character: White to Off-White Cyrstalline Solid
Dapoxetine Specifications:
COA
| Analysis | Specifications | Results |
| Appearance | White or almost white crystalline powder | Complies |
| Identification | IR | Complies |
| Loss on drying | ≤2.0% | 0.5% |
| Melting Point | 175°Cto 185°C | 180°C |
| Specific rotation | +128°±3° | 183°C+127°C |
| Chromatographic impurities | ||
| A. Single impurity | ≤0.2% | Complies |
| B. Total impurities | ≤0.5% | 0.3% |
| Assay | 98.0% to 102.0% | 99.2% |
| Conclusion: Conform to the Enterprise standard | ||
Dapoxetine Description:
Dapoxetine is a white powder substance and water-soluble. Taken 1–3 hours before sexual activity, it is rapidly absorbed in the body. Its maximum plasma concentration (Cm) is reached 1–2 hours after oral administration.
Randomized, double blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE.Different dosage has different impacts on different type of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress, interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE.
Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used.However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction.[10] Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.
Dapoxetine Application:
Due to the lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, and Citalopram have been used as clinical drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT about 2-9 time in comparison of three to eight times when Dapoxetine is used. However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence, an increasing adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours.
