99% Ketotifen Fumarate Powder CAS No.: 34580-14-8
Product Summary:
| Ketotifen fumarate, a Histamine H1 receptor antagonist, has been noted to inhibit histamine release from lymphocytes and monocytes at 0.1-10 μM. Ketotifen has demonstrated inhibiting characteristics against mast cell growth, therefore reducing myofibroblast hyperplasia. This compound has displayed induction capacities in primary necrosis of interleukin-5-treated eosinophils. Ketotifen fumarate is an inhibitor of PDE. |
99% Ketotifen Fumarate Powder CAS No.: 34580-14-8
Product Name:Ketotifen Fumarate
Synonym:Ketotifen fumarate [USAN:JAN]; 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one fumarate (1:1); Alaway; HC 20,511 fumarate; Ketotifen hydrogen fumarate; UNII-HBD503WORO; Zaditen; Zaditor; 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-, (E)-2-butenedioate (1:1); 4,9-Dihydro-4-(1-methylpiperidin-4-ylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophene-10-one fumarate; 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one; 1-methyl-4-(10-oxo-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)piperidinium; 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-but-2-enedioate
CAS Number: 34580-14-8
EINECS Number: 252-100-0
Molecular Formula: C23H23NO5S
Molecular Weight: 425.4974
InChI: 1 / C19H19NOS.C4H4O4 / c1-20-9-6-13 (7-10-20) 18-15-5-3-2-4-14 (15) 12-17 (21) 19- 16 (18) 8-11-22-19; 5-3 (6) 1-2-4 (7) 8 / h2-5,8,11H, 6-7,9-10,12H2,1H3; 1- 2H, (H, 5,6) (H, 7,8) / b; 2-1 +
Boiling Point: 488.9 ° C at 760 mmHg
Flash Point: 249.5 ° C
Steam Pressure: 1.05E-09mmHg at 25 ° C
Assay: 99%
Grade:Pharm Grade
Standard:EP
Packaging: 1kg / foil bag or according to customer's requirement
Appearance: white powder
Product Usage:
Antihistamines, asthma medications, for the prevention and treatment of bronchitis asthma
Ketotifen Fumarate Specification：
COA
ITEM | SPECIFICATION(EPV) | RESULTS |
APPEARANCE | WHITE TO BROWNISH-YELLOW, FINE, CRYSTALLINE POWDER | CONFORMS |
SOLUBILITY | SPARINGLY SOLUBLE IN WATER,SLIGHTLY SOLUBLE IN METHANOL,VERY SLIGHTLY SOLUBLE IN ACETONITRILE | CONFORMS |
IDENTIFICATION | TLC | COMPLIES |
IR SPECTRUM | COMPLIES | |
CLARITY AND COLOUR OF SOLUTION | CLEAR AND NOT MORE THAN Y4,BY4,B4 | <BY4 |
LOSS ON DRYING | NOT MORE THAN 0.5% | 0.2% |
SULPHATED ASH | NOT MORE THAN 0.1% | <0.1% |
PH | 3.0-4.0 | 3.6 |
CHLORIDE | NOT MORE THAN 150ppm | <150ppm |
HEAVY METALS | NOT MORE THAN 20ppm | <20ppm |
RELATED SUBSTANCES(HPLC) IMPURITY A IMPURITY G SINGLE UNKNOWN IMPURITY TOTAL IMPURITIES |
NOT MORE THAN 0.2% NOT MORE THAN 0.2% NOT MORE THAN 0.1% NOT MORE THAN 0.5% |
0.13% N.D. N.D. 0.13% |
ASSAY (POTEDNTIOMETRIC TITRATION) CALCULATED ON THE DRIED BASIS | BETWEEN 98.5% AND 101.0% | 99.3% |
CONCLUSION: | CONFORMS | |
Ketotifen Fumarate Description:
Ketotifen fumarate, a Histamine H1 receptor antagonist, has been noted to inhibit histamine release from lymphocytes and monocytes at 0.1-10 μM. Ketotifen has demonstrated inhibiting characteristics against mast cell growth, therefore reducing myofibroblast hyperplasia. This compound has displayed induction capacities in primary necrosis of interleukin-5-treated eosinophils. Ketotifen fumarate is an inhibitor of PDE.
