99%+ Purity Estrogen Steroid Estradiol Pure Powder

Product Details:

99%+ Purity Estrogen Steroid Estradiol Pure Powder

Estradiol Details:

Product name:Estradiol
Other name:Beta-Estradiol; B-estradiol; 17ß -Estradiol; β-estradiol; 1,3,5-estratriene-3,17beta-diol; 17beta-estradiol; 3,17beta-dihydroxy-1,3,5(10)-estratriene; dihydrofolliculin;
CAS:50-28-2
Einecs:200-023-8
MF:C18H24O2
MW:272.382
Purity:99%
Appearance:White crystalline powder
Usage:Estradiol is essential for the development and maintenance of female reproductive tissues

Estradiol Specifications:

COA

Estradiol Descriptions:

Estradiol, or more precisely, 17β-estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues[1] but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well

In the female, estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation. During pregnancy, estradiol increases due to placental production. In baboons, blocking of estrogen production leads to pregnancy loss, suggesting estradiol has a role in the maintenance of pregnancy. Research is investigating the role of estrogens in the process of initiation of labor. Actions of estradiol are required before the exposure of progesterone in the luteal phase.

Estradiol Effects:

Sexual development

The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after the menopause. Thus, estradiol produces breast development, and is responsible for changes in the body shape, affecting bones, joints, and fat deposition. Fat structure and skin composition are modified by estradiol.

Male reproduction

The effect of estradiol (and estrogens) upon male reproduction is complex. Estradiol is produced by action of aromatase mainly in the Leydig cells of the mammalian testis, but also by some germ cells and the Sertoli cells of immature mammals.It functions (in vitro) to prevent apoptosis of male sperm cells.

Several studies have noted sperm counts have been declining in many parts of the world, and estrogen exposure in the environment has been postulated to be the cause.Suppression of estradiol production in a subpopulation of subfertile men may improve the semen analysis.

Males with sex chromosome genetic conditions, such as Klinefelters syndrome, will have a higher level of estradiol.

Bone

Estradiol has a profound effect on bone. Individuals without it (or other estrogens) will become tall and eunuchoid, as epiphyseal closure is delayed or may not take place. Bone structure is affected also, resulting in early osteopenia and osteoporosis.Also, women past menopause experience an accelerated loss of bone mass due to a relative estrogen deficiency.

Liver

Estradiol has complex effects on the liver. It can lead to cholestasis. It affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood clotting.

Brain

Estrogens can be produced in the brain from steroid precursors. As antioxidants, they have been found to have neuroprotective function.

The positive and negative feedback loops of the menstrual cycle involve ovarian estradiol as the link to the hypothalamic-pituitary system to regulate gonadotropins.

Gynecological cancers

Estradiol has been tied to the development and progression of cancers such as breast cancer, ovarian cancer and endometrial cancer.

Estradiol has complex effects on the liver. In high amounts, it can lead to cholestasis. Estradiol affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood clotting.

Estrogen affects certain blood vessels. Improvement in arterial blood flow has been demonstrated in coronary arteries.

Several benign gynecologic conditions are dependent on estrogen, such as endometriosis, leiomyomata uteri, and uterine bleeding.

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