99%+ Purity Tetracaine Hydrochloride (Tetracaine HCL) CAS :136-47-0
Product Details:
| Tetracaine HCL Powder Information | ||
| Tetracaine HCL Price | 1kg | According to your needs |
| 25kg | According to your needs | |
| 100kg | According to your needs | |
| Packaging | 25kg/drum | |
| Delivery time | About 7 days | |
| Shipping | EMS, Hongkong Post, DHL, TNT, Fedex and so on. | |
| Payment terms | WU, MG, Bitcoin, T/T | |
| Minimum order | 1kg powder | |
Tetracaine Hydrochloride Local Pharmaceutical Anaesthetics White Powder Tetracaine HCL
Product Name:Tetracaine hydrochloride
Synonym:Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride;
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
CAS NO.:136-47-0
EINECS:205-248-5
MF:C15H25ClN2O2
MW:300.82
Melting point:149°C
Assay:99%
Grade:Pharmaceutical Grade
Storage:Closed, confined and shading preservation
Appearance :White Crystal Powder
Tetracaine Hydrochloride Specifications:
COA
| Test Items | Specification | Test Results |
| Appearance | Fine, white, crystalline, odorless powder | confirm |
| Identification | ABC in Pass | confirm |
| Solubility | Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene | confirm |
| USP Reference standards | USP Tetracaine Hydrochloride RS. USP Endotoxin RS. | confirm |
| Melting point | 145~150 degree | 146.0~147.5 degree |
| Chromatographic purity | In Pass | confirm |
| Related substance | Not more than the reference solution 0.05% | confirm |
| Heavy metals | ≤10ppm | confirm |
| PH | 4.5-6.5 | 5.8 |
| Residue on ignition | ≤0.10% | 0.05% |
| Loss on Drying | ≤ 0.5% | 0.19% |
| Assay | 98.0 -101.0% | 100.1% |
| Conclusion | Confirms USP 32 | |
Tetracaine Hydrochloride Description:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine is a weak base, therefore, significant changes in the rate of ionised lipid soluble drug uptake may occur with changes in the acid base balance.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
Tetracaine Hydrochloride Application:
It has been used in spinal anesthesia.In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores.Tetracaine is an allosteric blocker of channel function.At low concentrations,tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
A- For block anesthesia and epidural anesthesia.
B- Also used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
C- As painkillers of injection in the medicament.
D- Also used in suppository and ointment preparation, etc.
Tetracaine Hydrochloride Use:
A) In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
B) Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5M(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
C) Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
