99%+ Purity Procaine Hydrochloride (Procaine HCL) CAS No.:614-39-1

Product Details:

99%+ Purity Procaine Hydrochloride (Procaine HCL) Local Anesthetic Powder for Pain Killer CAS No.:614-39-1

Procaine Hydrochloride Chemical name:4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride
Synonyms :Amide, Procaine Hydrochloride, Procainamide Hydrochloride ; Novocainamide Apo-Procainamide Hydrochloride ;Rhythmin ; Procanbid Hydrochloride ; Novocainamide Hydrochloride ; Novocamid Hydrochloride ; Procainamide HCl Procanbid
Molecular weight:271.79
Molecular formula:C13H21N3O.HCl
CAS Number:614-39-1
Assay: 99%
EINECS: 200-077-2
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Appearance: White crystalline powder
Storage instructions Store at +4°C.
Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overview :Soluble in water to 100 mM and in ethanol to 100 mM
Usage: Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.

Procaine Hydrochloride Specifications:

COA

HPLC

Procaine Hydrochloride Description:

Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.

Procaine HCL is actually a very simple combination of two B vitamins, PAPA (P-aminobenzoic acid) and DEAE (diethylaminoethanol) buffered and stabilized with benzoic acid and potassium metabisulfite for more effectiveness inside the body. Procaine hydrochloride is a compound combination of PABA and DEAE, a vitaminic substance first synthesized in 1905 by a German chemist, Dr. Albert Einhorn, who was looking for a simple, non-addictive anesthetic.

Procine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.

Procaine HCl (procaine hydrochloride) is the active ingredient in Gerovital H3(GH3) and in the Vitacels 3 through 8. Procaine HCl is broken down rapidly by enzymes in the blood stream into PABA and DEAE. The PABA and DEAE are rapidly conjugated and removed from the blood and excreted from the body. Because of this procaine HCl and its breakdown products (metabolites) are unable to get into the cells in any great quantity to produce benefits. Procaine HC will produce some benefits by itself, but they are very limited.

Procaine Hydrochloride Application:

Procaine HCl is a local anesthetic drug of the amino ester group.It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry.Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine.It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.

Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.

Application of procaine leads to the depression of neuronal activity.The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions.Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage.Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed.Procaine may also induce weakening of the myocardium leading to cardiac arrest.

Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling.Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA.About one in 3000 people have an atypical form of pseudocholinesterase,[citation needed] which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.

Procaine Hydrochloride ( Procaine HCL ) and Complexed Procaine:

Procaine HCL is actually a very simple combination of two B vitamins, PAPA (P-aminobenzoic acid) and DEAE (diethylaminoethanol) buffered and stabilized with benzoic acid and potassium metabisulfite for more effectiveness inside the body. Procaine hydrochloride is a compound combination of PABA and DEAE, a vitaminic substance first synthesized in 1905 by a German chemist, Dr. Albert Einhorn, who was looking for a simple, non-addictive anesthetic.

Why the stabilized procaine HCl was more effective than the unstabilized solutions?

The chemistry of procaine showed that procaine in the bloodstream only has a half-life of 0.6 of a minute before destroyed by the enzyme pseudocholinesterase in the bloodstream. The stabilized procaine HCl solution had a half-life of over 6 hours (six hundred times greater active life span in the blood).
The increased life span was due to the fact that the benzoic acid complexed with the procaine HCl forming a double salt of amino groups on the procaine molecule. The HCl hooked to the tertiary amino group on the diethylaminoethanol part of the molecule while at an acid pH of 3-4 the benzoic acid hooked on the p-amino group of the PABA part of the procaine molecule.
This double salt formation caused the procaine molecule to fold over covering the ester linkage, causing steric hindrance, which made the ester linkage of the procaine inaccessible to the splitting action of the pseudocholinesterase enzyme. This extended the useful life of the procaine in the bloodstream giving it more time to be assimilated into the cells.
The amount of benzoic acid used to stabilize the solution by Dr Aslan only complexed 15 mgs of the 100 mgs of procaine HCl in her injectable solution. This left 85 mgs or 85% of the active material to be destroyed in less than 10 minutes by the enzymes in the blood. So naturally one would ask, why not complex the whole 100 mgs of the procaine HCl thus making it 6 times more effective.
However there was a problem the amount of benzoic acid necessary to complex 100 mgs of the Procaine HCl would be more than the law would allow. The law only allows 0.1% of benzoates in any food product. Benzoic acid provides no benefit to the cell. Higher concentrations would be a powerful allergen to many people. The problem was to protect all of the procaine HCl with something other than benzoic acid that could possibly help in the cellular function of the procaine HCl.

Procaine HCl and its effects on the diseased cells.

In summary, the procaine HCl molecules being composed of a molecule of PABA (p-aminobenzoic acid), a B vitamin, hooked through an ester linkage to DEAE (diethylaminoethanol), a precursor to the B vitamin choline, functioned in the body as a true vitamin molecule at a cellular level effecting cell membranes.

Since the diseased state of a cell that is responsible for most degenerative diseases involves or is precipitated by malfunctions of the cell membranes, the inability of the cell to repair and rebuild new healthy membranes, it followed that this compound procaine hydrochloride ( procaine HCl ) could be very useful in helping degenerative diseases by improving the ability of the cell to renew, repair and rebuild diseased cellular membranes thus normalizing cellular function. The normalized healthy cell in turn would correct the functional problems caused by the diseased state.

Dr. Ana Aslan continued the research of several French scientists which earlier showed the procaine HCl injections over a period of time would reverse the effects of various forms of arthritis. She stated using injections of procaine HCl on the geriatric patients in her clinic. The results were very promising. However there was a problem the injectable solutions would become cloudy after a short period of time, which made them unusable. She did that which was a common practice at that time (1950's). To stabilize the injectable solution she added benzoic acid, potassium metabisulfite, and disodium phosphate.

These additions stabilized the procaine Hcl solution by maintaining the pH around 3.3. She found that this stabilized procaine HCl was far more effective than the unstabilized procaine HCl solutions. Dr. Aslan's clinical research using Gerovital H3 (GH-3)through the years has contributed greatly to the improved health of tens of thousands of people throughout the world. She died in 1988 at the age of 91. Her contributions to mankind are of great importance. She was truly one of the great scientists of our time.

Please send your inquiry with DESTINATION,PRODUCT NAMES and QUANTITIES directly to us