99%+ Purity Hydrochlorothiazide Powder CAS No.: 58-93-5
Product Summary:
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Hydrochlorothiazide is used to treat high blood pressure (hypertension). Hydrochlorothiazide is also used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. |
99%+ Purity Hydrochlorothiazide Powder CAS No.: 58-93-5
Hydrochlorothiazide Details:
Hydrochlorothiazide Product Name: Hydrochlorothiazide
Hydrochlorothiazide Synonyms: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide; 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-,1,1-dioxide; 3,4-Dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide;6-chloro-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide;6-Chloro-3,4-dihydro-7-sulphamoyl-1,2,4-ben-zoth-iadi-azine1,1-dioxcide;6-chloro-7-sulfamoyl-3,4-dihydro-2h-1,2,4-benzothiadiazine; 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide;6-chloro-7-sulfamoyl-3,4-dihydro-2h-1,2,4-benzothiadiazine-1,1-dioxide
Hydrochlorothiazide CAS: 58-93-5
Hydrochlorothiazide MF: C7H8ClN3O4S2
Hydrochlorothiazide MW: 297.74
Hydrochlorothiazide EINECS: 200-403-3
Hydrochlorothiazide Product Categories: Losartan Potassium & Hydrochlorothiazide; Xanthones; Heterocyclic Compounds; Heterocycles; Inhibitors; Ion transporter and other ion channel;Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds; API; ESIDRIX; Other APIs; Pyrimidines, Purines
Hydrochlorothiazide Specification:
COA
| Contents | Specification | Results |
| Characteristics | White or almost white Crystalline powder | complies |
| Solubility | Very slightly soluble in water, slightly soluble in alcohol, Soluble in acetone and dilute solutions of alkalines hydroxides | complies |
| Coalition Band | 266°Cto270°C,with decomposition | complies |
| Identification | Meets the requirements | complies |
| Acidity or alkalinity | ≤0.4ml | 0.2ml |
| Chloride | ≤ 0.03% | < 0.01% |
| Selenium | < 0.003% | < 0.003% |
| Heavy metal | < 0.001% | < 0.001% |
| Residue on ignition | ≤0.1% | 0.03% |
Related Substances a)Any peak b)Sum of peak | ≤0.5% ≤1.0% | 0.28% 0.35% |
4-Amino-6-chloro-1.3- -Benzenedisulfonamide | < 1% | 0.39% |
| Loss on drying | ≤ 0.5% | 0.04% |
| Organic volatile impurities | Meets the requirements | Complies |
| Assay | 98.0-102.0%(on the dried basis sub) | 99.58 % |
| Conclusion: It complies with the requirements of the USP32. | ||
Hydrochlorothiazide Description:
Hydrochlorothiazide (abbreviated HCTZ, HCT, or HZT), is a diuretic medication often used to treat high blood pressure and swelling due to fluid build up. Other uses include diabetes insipidus, renal tubular acidosis, and to decrease the risk of kidney stones in those with high calcium level in the urine. For high blood pressure it is often recommended as a first line treatment. HCTZ is taken by mouth and may be combined with other blood pressure medications as a single pill to increase the effectiveness.
Hydrochlorothiazide Application:
Hydrochlorothiazide is frequently used for the treatment of hypertension, congestive heart failure, symptomatic edema,diabetes insipidus, renal tubular acidosis.It is also used for the prevention of kidney stones in those who have high levels of calcium in their urine.
Most of the research supporting the use of thiazide diuretics in hypertension was done using chlorthalidone, a different medication in the same class. Some more recent studies have suggested that chlorthalidone might be the more effective thiazide diuretic.
It is also sometimes used for treatment of hypoparathyroidism,hypercalciuria, Dent's disease, and Ménière's disease. For diabetes insipidus, the effect of thiazide diuretics is presumably mediated by a hypovolemia-induced increase in proximal sodium and water reabsorption, thereby diminishing water delivery to the ADH-sensitive sites in the collecting tubules and increasing the urine output.
Thiazides are also used in the treatment of osteoporosis. Thiazides decrease mineral bone loss by promoting calcium retention in the kidney, and by directly stimulating osteoblast differentiation and bone mineral formation.
It may be given together with other antihypertensive agents in fixed combination preparations, such as inhydrochlorothiazide/losartan.
