99%+ Purity Aicar (Acadesine) Raw Sarm Powder CAS No.: 2627-69-2

Product Details:

 

Aicar Information
Aicar Price10gAccording to your needs
50gAccording to your needs
100gAccording to your needs
Packagingdiscreet packages
Delivery timeAbout 7 days
ShippingEMS, Hongkong Post, DHL, TNT, Fedex and so on.
Payment termsWU, MG, Bitcoin, T/T
Minimum order

5g powder

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99%+ Purity Aicar (Acadesine) Raw Sarm Powder CAS No.: 2627-69-2

 

Product Name:Aicar
Aicar Alias:Acadesine
Aicar CAS:2627-69-2
Aicar Molecular Formula:C9H14N4O5
Aicar Molecular weight:258.23
Aicar Apperance:Off-White Powder
Assay:99%min
Usage:Pharmaceutical intermediates. For the treatment of cardiovascular diseases

 

Aicar (Acadesine) Specifications:

COA


Item
SpecificationResult
AppearanceWhite powderComplies
Related substance (HPLC)Total impurity ≤0.5%
Max single impurity ≤0.1%
0.2%
0.06%
OdorCharacteristicComplies
Assay99%99.8%
Sieve analysis100% pass 80 meshComplies
Loss on Drying
Residue on Ignition
≤1.0%
≤1.0%
0.12%
0.09%
Heavy Metal<10ppmComplies
As<0.1ppm0.05ppm
Pb<0.1ppm0.05ppm
Cd<0.1ppm0.05ppm
Residual Solvents<100ppmComplies
Residual PesticideNegativeComplies
Microbiology  
Total Plate Count<1000cfu/gComplies
Yeast & Mold<100cfu/gComplies
E.ColiNegativeComplies
SalmonellaNegativeComplies

 

Aicar (Acadesine) Description:

Aicar is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with Aicar mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

 

Aicar (Acadesine) Application:

Aicar can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide's presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

 

Aicar (Acadesine) Function:

(1). AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes.

(2). Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).

(3). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

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